Julie A Leary PhD. Professor of Biochemistry Department of Molecular and Cellular Biology Univers...

Thursday, February 16, 2012 6:00 pm to 9:30 pm

Location:
Crowne Plaza Hotel
Foster City, CA

Dinner reservations required by Monday February 13 at 6:00 PST, 2012****

Julie A Leary PhD. Professor of Biochemistry
Department of Molecular and Cellular Biology

University of California, Davis**** *********************************************************************************************************************TITLE:

"Protein-Carbohydrate Interactions: Ion Mobility and RAPTOR Analysis for Isomeric Differentiation"
ABSTRACT:

This seminar will present IM data showing separation and detection of isomeric glycosaminoglycans (GAG) both with and without protein complexation. Chemokine proteins are involved in inflammation and as such complex with GAG during the activation step of chemotaxis. Comparison of different chemokine conformations suggests that the GAG will complex to different areas of the protein and that sulfation pattern may play a part in complexation. A relatively new modeling program, RAPTOR, is used for determining theoretical cross sections and overall conformation of proteins for which there is no crystal or NMR structure. Both RAPTOR and IM provide valuable information on isomeric separation, identification and conformation of both carbohydrate alone, and with its' protein partner.SPEAKER BIOGRAPHY:Julie A. Leary is Professor of Biochemistry in the Department of Molecular and Cellular Biology at the University of California, Davis. Her research efforts focus on the use of mass spectrometry as an important tool in chemical biology. She is particularly interested in developing new analytical methods for analyzing carbohydrate:protein and protein-protein complexes as well as investigating enzyme kinetics and mechanisms of enzyme catalysis using mass spectrometry. After receiving her Ph.D. from the Massachusetts Institute of Technology under the mentorship of Prof. Klaus Biemann, Dr. Leary moved to U.C. Berkeley where she was Director of Analytical Facilities and Adjunct Professor of Chemistry. In 2000, she won the prestigious international award, The Biemann Medal, for her pioneering work on metal-coordinated oligosaccharides and their stereochemical differentiation using mass spectrometry. In 2010 she was elected as Fellow to the American Association for the Advancement of Science. She has been on the editorial board of several journals and has served on numerous NIH study section panels as Chair and reviewer. She is also a member of the Advisory Boards for the Complex Carbohydrate Research Center in Georgia and the Joint Bioenergy Energy Institute at U.C. Berkeley/DOE.

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If you would like to become a sponsor or a member, please contact Ahmed Elbaggari.

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We look forward to seeing you at the next meeting!

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