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When

Jan 9, 2009 (Friday)

Where

University of California (UC) Berkeley

200 Wheeler Hall
Berkeley, CA 94720
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What
Seminar | January 9 | 2-3 p.m. | 3 LeConte HallSpeaker/Performer: Prof. Stuart Lindsay, Arizona State Univ. Center for Single Molecule BiophysicsSponsor: Berkeley Nanosciences and N...
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Description

Seminar | January 9 | 2-3 p.m. | 3 LeConte Hall

Speaker/Performer: Prof. Stuart Lindsay, Arizona State Univ. Center for Single Molecule Biophysics

Sponsor: Berkeley Nanosciences and Nanoengineering Institute

Many schemes for very long reads of DNA sequence propose to pass the DNA through a nanopore so that each base appears at a reader in exactly the order in which it is incorporated into the parent polymer.
However, a reading device with single base resolution is required.

Electron tunneling has been proposed as a probe because the phenomenon is highly localized, and we have shown that the base composition of DNA oligomers can indeed be read by a chemically-functionalized tunneling probe. However, single base resolution cannot be obtained because of the size of the tunnel junction that is required to support a significant current.

Smaller single molecule targets are readily detected, and an alternative tunneling scheme will be described.

Event Contact: 510-643-6681

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